ParkinsonFranceV1, Main, Exploration, bibRecord, 000480

The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers*

Identifieur interne : 000480 ( Main/Exploration ); précédent : 000479; suivant : 000481

The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers*

Auteurs : Cristiane Latge ; Katia M. S. Cabral ; Guilherme A. P. De Oliveira ; Diana P. Raymundo ; Julia A. Freitas ; Laizes Johanson ; Luciana F. Romão ; Fernando L. Palhano ; Torsten Herrmann ; Marcius S. Almeida ; Debora Foguel

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2015.

RBID : PMC:4536457

English descriptors

KwdEn :
- Animals, Biopolymers (metabolism), Cell Line, Crystallography, X-Ray, Humans, Mice, Nerve Growth Factors (chemistry), Nerve Growth Factors (physiology), Neuroprotective Agents, Nuclear Magnetic Resonance, Biomolecular, Protein Conformation, Structure-Activity Relationship, alpha-Synuclein (metabolism).
MESH :
- chemical , chemistry : Nerve Growth Factors.
- chemical , metabolism : Biopolymers, alpha-Synuclein.
- chemical , physiology : Nerve Growth Factors.
- Animals, Cell Line, Crystallography, X-Ray, Humans, Mice, Neuroprotective Agents, Nuclear Magnetic Resonance, Biomolecular, Protein Conformation, Structure-Activity Relationship.
mix :
- Parkinson disease, neurodegeneration, neurotrophic factor, protein dynamic, protein structure, α-synuclein (a-synuclein).

Abstract

Background: Cerebral dopamine neurotrophic factor (CDNF) is a promising therapeutic agent for treating Parkinson disease.

Results: We determined the solution structure of CDNF and demonstrated its neuroprotective effects against insults caused by α-synuclein oligomers.

Conclusion: We identified structural features of CDNF that might correspond with its physiological activity.

Significance: This work strengthens the therapeutic relevance of using CDNF to treat neurodegenerative diseases.

Url:

DOI: 10.1074/jbc.M115.662254
PubMed: 26149686
PubMed Central: 4536457

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Cerebral dopamine neurotrophic factor (CDNF) is a promising therapeutic agent for treating Parkinson disease.</p>
<p><bold>Results:</bold>
 We determined the solution structure of CDNF and demonstrated its neuroprotective effects against insults caused by α-synuclein oligomers.</p>
<p><bold>Conclusion:</bold>
 We identified structural features of CDNF that might correspond with its physiological activity.</p>
<p><bold>Significance:</bold>
 This work strengthens the therapeutic relevance of using CDNF to treat neurodegenerative diseases.</p>
</div>
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La maladie de Parkinson en France (serveur d'exploration)

The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers*

The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers*

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.